the effect of topical nifedipine in treatment of chronic anal fissure
Authors
abstract
chronic anal fissure is the most common cause of anal pain associated with internal anal sphincter hypertonia. reduction of hypertonocity is a special treatment for fissure healing. for this purpose chronic anal fissures were conventionally treated by anal dilatation or by lateral sphincterotomy. however, both of these methods may cause a degree of incontinence in some patients. the uptake of medical therapies that create a reversible chemical sphincterotomy has recently become widespread. the aim of this prospective clinical trial study was to assess the effectiveness of nifedipine in healing anal fissure, a calcium channel blocker that reduces sphincter pressure. a single-blind randomized comparative trial was setup to compare traditional treatment with stool softeners and 2% lidocaine cream against 0.5% nifedipine cream for 4 weeks. 110 patients were included in this study, 60 patients in the nifedipine group and 50 patients in the control group and the therapeutic outcome and side effects were recorded. healing had occurred in 70% of patients in the nifedipine group and in 12% of patients in the control group after 4 weeks treatment (p < 0.005). recurrence of symptoms occurred in four of healed patients in the nifedipine group and three patients in the control group in two months. the final result of nifedipine application after 12 months follow up was recurrence in 11 patients (26.19%). mild headache occurred in four patients (6.6%) of the nifedipine group. patients in the nifedipine group showed significant healing and relief from pain compared with patients in the control group. recurrence rate with nifedipine use in spite of control of predisposing factors such as constipation was significant. another finding was low complication rate with this treatment.
similar resources
comparison of topical nifedipine with oral nifedipine for treatment of anal fissure: a randomized controlled trial
background medical sphincterotomy has gained popularity as a treatment for anal fissure. calcium channel blockers in topical forms could also be appropriate with low adverse effects. objectives this was a prospective randomized controlled trial to compare topical and oral nifedipine in the treatment of chronic anal fissure. patients and methods a prospective randomized controlled trial was cond...
full textComparison of Topical Nifedipine With Oral Nifedipine for Treatment of Anal Fissure: A Randomized Controlled Trial
BACKGROUND Medical sphincterotomy has gained popularity as a treatment for anal fissure. Calcium channel blockers in topical forms could also be appropriate with low adverse effects. OBJECTIVES This was a prospective randomized controlled trial to compare topical and oral nifedipine in the treatment of chronic anal fissure. PATIENTS AND METHODS A prospective randomized controlled trial was ...
full textEvaluation of the Efficacy of Topical Hydrocortisone in the Treatment of Anal Fissure in Patients Undergoing Pharmacological Treatment
Background and Objective: Anal fissure can be associated with trauma caused by passing hard stools or prolonged diarrhea. The present study aimed to determine the effectiveness of topical hydrocortisone in the treatment of anal fissures in patients under medical treatment referred to Fatemi Hospital and Kausar Clinic of Ardabil Medical Sciences, Ardabil, Iran, in 2019. Materials and Methods: I...
full textTopical Diltiazem versus topical Glyceryl trinitrate (GTN) in the treatment of chronic anal fissure: Prospective study
full text
Effectiveness of 0.2% Glyceryl Trinitrate and 0.5% Nifedipine in the Treatment of Chronic Anal Fissure.
INTRODUCTION Anal fissure is an ischemic ulcer caused by combination of spasm of internal anal sphincter and poor blood supply to the posterior midline of anal canal. This study aimed to assess the efficacy of Glyceryl Trinitrate and Nifedipine in the treatment of chronic anal fissure. METHODS Ninety patients with symptomatic anal fissure in Kathmandu Medical College Teaching Hospital are all...
full textTopical glyceryl trinitrate in the treatment of anal fissure.
AIM the aim of this study was to assess the effectiveness of topical glyceryl trinitrate (GTN) in the treatment of anal fissure. PATIENTS eighty consecutive patients were randomized to receive 0.2% GTN gel twice a day during a minimum of 6 weeks. Of these 80 patients 34 were males and 46 female, with ages between 20 and 78 years. All patients underwent a work-up that included gender, age, sym...
full textMy Resources
Save resource for easier access later
Journal title:
acta medica iranicaجلد ۲۰۱۰، شماره ۱۰، صفحات ۲۹۵-۲۹۹
Hosted on Doprax cloud platform doprax.com
copyright © 2015-2023